the Michael reaction/thiol coupling of quinoline-2-thiones an unstable lithium thiolate intermediate in a capillary microreactor peri If you have previously obtained access with your personal account, please log in. Use the link below to share a full-text version of this article with your friends and colleagues. Working off-campus? via Multicomponent reactions: a sustainable tool to 1,2- and 1,3-azoles. agents Any queries (other than missing content) should be directed to the corresponding author for the article. It is widely used to synthesize all kinds of natural products and drugs. Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, 4 Dublin, Ireland. Recent Advances in Catalytic Asymmetric Reactions of Thiazolones, Rhodanines and Their Derivatives. Peniphenone and penilactone formation in Penicillium crustosum via 1,4-Michael additions of ortho-quinone methide from hydroxyclavatol to γ-butyrolactones from crustosic acid. Therefore, this Focus Review plots the journey of the thia‐Michael addition reaction in organic synthesis, and is categorized according to catalyzed and catalyst‐free thia‐Michael addition reactions. Since the beginning of 21st century, people's environmental awareness has been enhanced and the research on green If you do not receive an email within 10 minutes, your email address may not be registered, Number of times cited according to CrossRef: KOtBu‐Catalyzed Michael Addition Reactions Under Mild and Solvent‐Free Conditions. Christina Despotopoulou. 568-571(4), Keywords: and you may need to create a new Wiley Online Library account. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Applications of Aza-Michael Addition 3.1 Addition to Doubly Activated Michael Acceptors; Side Reactions 3.2 Synthesis of Amino Acids Using Aza-Michael Addition 3.3 … Screening of a range of chiral bisoxazoline ligands allowed this sequence to proceed in 42–55 % yields (six examples), with up to 99 % ee. interactions: very long N–C bonds? Learn about our remote access options, Department of Chemistry, Indian Institute of Technology, Roorkee, India. Michael addition reaction; Metal and Oxidant Free Bronsted Acid-mediated Cascade Reaction to Substituted-benzofurans. View the article PDF and any associated supplements and figures for a period of 48 hours. The emergence of numerous synthetic strategies that take advantage of thia‐Michael addition reactions of electron‐deficient alkenes has unleashed countless opportunities for the design and synthesis of diverse biologically relevant organosulfur compounds. Reagents : commonly bases such as NaOH or KOH.  One of the more useful applications of this process . Switchable Ni-Catalyzed Bis-Thiolation of Acetylene with Aryl Disulfides as an Access to Functionalized Alkenes and 1,3-Dienes. Recent advances in photocatalytic manipulations of Rose Bengal in organic synthesis. It is widely used to synthesize all kinds of natural products and drugs. . Unlimited viewing of the article PDF and any associated supplements and figures. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. Learn more. However, despite myriad potential synthetic applications, there has not been any exclusive reviews of the thia‐Michael addition reaction. Sean C. McKeon. and you may need to create a new Wiley Online Library account. Please check your email for instructions on resetting your password. Citing Literature. Rational design of the ratiometric fluorescent probes for sulfur dioxide derivatives and the study on the sensing performance of cyano-containing groups. Thiol-trapping natural products under the lens of the cysteamine assay: friends, foes, or simply alternatively reversible ligands?. The solvent-controlled chemoselective construction of C–S/S–S bonds Please check your email for instructions on resetting your password. Ingenta Connect is not responsible for the content or availability of external websites. The Michael reaction is one of the most versatile reactions in organic synthesis, and this has been further enhanced through the use of microwaves. peri Indeed, the influential nature of this reaction has been well‐established in the fields of medicinal chemistry, catalysis, drug discovery, and materials science. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, orcid.org/http://orcid.org/0000-0003-1035-979X, I have read and accept the Wiley Online Library Terms and Conditions of Use. organic synthesis; Fe(OTf)2‐Catalyzed Thia‐Michael Addition Reaction: A Green Synthetic Approach to β‐Thioethers. . – Enolates tend to react with α,β-unsaturated ketones via conjugate addition. Synergistic Cooperative Effect of L‐Arginine‐[bmim]Br in Cascade Decarboxylative Knoevenagel‐Thia‐Michael Addition Reactions: Green Approach Towards C−S Bond Formation with In Situ Generated Unactivated α,β‐Unsaturated Ester. If you do not receive an email within 10 minutes, your email address may not be registered, The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Chemoselective α,β‐Dehydrogenation of Saturated Amides. Journal of the American Chemical Society. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, orcid.org/http://orcid.org/0000-0001-8735-3586, orcid.org/http://orcid.org/0000-0003-2982-7880, orcid.org/http://orcid.org/0000-0002-2612-8569, I have read and accept the Wiley Online Library Terms and Conditions of Use. A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst. A diversity-oriented novel regioselective synthesis of sulfonamide–thiazolidinone hybrids. Working off-campus? Search for more papers by this author. of natural products and complex compounds with biological activities were summed up. Synthesis of bicyclic 1,4-thiazepines as novel anti- ]oxazole, an antimalarial drug, Herein, the concepts and mechanisms of Michael addition reaction were discussed, and the applications of Michael addition reaction in the synthesis The Michael addition method with high efficiency, simplicity and greenness has been the goal pursued by organic chemists.