The crude acid chloride is then isolated and reacted with the amine in a similar manner as described above.

Click on the reaction arrow to visit the page. The reaction of acid chlorides and amines to form amides is very general. DCM, THF, or DMF ). DCM, THF, or DMF). Mechanism. TEA or DIEA) in an aprotic solvent (ex. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Like amines, various nomenclature rules may be used to name amides, but all include use of the class-specific suffix -amide: Amides can be produced when carboxylic acids react with amines or ammonia in a process called amidation. Typically the reaction takes place at RT with a suitable base (ex. Examples. The reaction of acid chlorides and amines to form amides is very general. Starting from the carboxylic acid a two step process is often used. A list of common conditions for the conversion of an amine to an amide via coupling reactions. Amides are molecules that contain nitrogen atoms connected to the carbon atom of a carbonyl group. The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. amine: organic molecule in which a nitrogen atom is bonded to one or more alkyl group. TEA or DIEA) in an aprotic solvent (ex. amide: organic molecule that features a nitrogen atom connected to the carbon atom in a carbonyl group Thionyl chloride (SOCl2) or oxalyl choride [(COCl)2] is used to make the acid chloride. Typically the reaction takes place at RT with a suitable base (ex.